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. 2018 May 11;8(12):3284–3307. doi: 10.7150/thno.25220

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Functionalization of IONPs with silica. (A) General procedures for coating silica on IONPs. Reprinted with permission from ¹¹⁶, copyright 2006. (B) La Mer-like diagram: hydrolyzed TEOS (monomers) concentration against time for homogeneous nucleation and heterogeneous nucleation and TEM images of different Fe₃O₄@SiO₂ NPs. Reprinted with permission from ¹¹⁷, copyright 2012. (C) TEM images and magnetization curves of Fe₃O₄@SiO₂ hollow mesoporous spheres with varying Fe₃O₄ content. Reprinted with permission from ¹¹⁸, copyright 2010. (D) Schematic illustration of the preparation of IOMSN@uIO(DOX)-FA NPs and its application as a MRI-guided stimuli-responsive theranostic platform for effective targeted chemotherapy of cancer. Reprinted with permission from ¹¹⁹, copyright 2018.