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hSSTR2 transduction effect on 68Ga-DOTATOC uptake. (A) A significant increase in 68Ga-DOTATOC uptake in the select TD clones of A549 and Panc-1 cells compared to WT cells was observed. The cellular uptake of 68Ga-DOTATOC was specific and was completely blocked by competitive inhibition from the SST analog, octreotide. (B) In vivo, 68Ga-DOTATOC PET SUVmean was significantly higher in the A549TD and Panc-1TD compared to A549WT and Panc-1WT, respectively.
