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. 2018 May 23;8(12):3380–3391. doi: 10.7150/thno.24017

Figure 8.

Figure 8

Hematoxylin and eosin (H&E) staining of A549 (A-H) and Panc1 (I-P) of representative tumor specimens 22 days after PRRT at 100x (A-D, I-L) and 200x (E-H, M-P) magnification. A549WT (A, E) and Panc-1WT (E, M) tumors sections demonstrate high tumor cellularity and high nuclear to cytoplasmic ratio. A549TD (B, F) and Panc-1TD (J, N) tumors showing extensive areas of tumor necrosis with scant cellularity. 50% (C, G) and 10% (D, H) mixed population A549 TD tumors demonstrated much reduced tumor cellularity compared to WT tumors, and large areas of necrosis; there was extensive cellular ballooning and pyknotic cell nuclei. (F-G) 50% (K, O) and 10% (L, P) mixed population Panc-1 TD tumors demonstrate scant cellularity, extensive areas of necrosis and small tumor cell islands with cellular ballooning and pyknotic cell nuclei at the periphery.