Table 3.
Accuracy of Patient-Reported Clinical Symptoms (Assessed Using EEsAI PRO Score) to Detect Endoscopic Remission
| EEsAI PRO score cutoff | Cumulative remissions,a n (%) | Cumulative frequency,b n (%) | PPV, % | NPV, % | Sensitivity, % | Specificity, % | Accuracy, % |
|---|---|---|---|---|---|---|---|
| Endoscopic inflammatory remission | |||||||
| 15 | 55/96 (57.3) | 96/269 (35.7) | 57.3 | 64.2 | 47.0 | 73.0 | 61.7 |
| 20 | 63/111 (56.8) | 111/269 (41.3) | 56.8 | 65.8 | 53.8 | 68.4 | 62.1 |
| 25 | 63/112 (56.3) | 112/269 (41.6) | 56.3 | 65.6 | 53.8 | 67.8 | 61.7 |
| 30 | 85/162 (52.5) | 162/269 (60.2) | 52.5 | 70.1 | 72.6 | 49.3 | 59.5 |
| 35 | 87/180 (48.3) | 180/269 (66.9) | 48.3 | 66.3 | 74.4 | 38.8 | 54.3 |
| Endoscopic fibrotic remission | |||||||
| 15 | 66/96 (68.8) | 96/269 (35.7) | 68.8 | 52.6 | 44.6 | 75.2 | 58.4 |
| 20 | 75/111 (67.6) | 111/269 (41.3) | 67.6 | 53.8 | 50.7 | 70.2 | 59.5 |
| 25 | 75/112 (67.0) | 112/269 (41.6) | 67.0 | 53.5 | 50.7 | 69.4 | 59.1 |
| 30 | 104/162 (64.2) | 162/269 (60.2) | 64.2 | 58.9 | 70.3 | 52.1 | 62.1 |
| 35 | 114/180 (63.3) | 180/269 (66.9) | 63.3 | 61.8 | 77.0 | 45.5 | 62.8 |
| Total endoscopic remission (inflammatory and fibrotic) | |||||||
| 15 | 43/96 (44.8) | 96/269 (35.7) | 44.8 | 79.2 | 54.4 | 72.1 | 66.9 |
| 20 | 48/111 (43.2) | 111/269 (41.3) | 43.2 | 80.4 | 60.8 | 66.8 | 65.1 |
| 25 | 48/112 (42.9) | 112/269 (41.6) | 42.9 | 80.3 | 60.8 | 66.3 | 64.7 |
| 30 | 63/162 (38.9) | 162/269 (60.2) | 38.9 | 85.0 | 79.7 | 47.9 | 57.2 |
| 35 | 63/180 (35.0) | 180/269 (66.9) | 35.0 | 82.0 | 79.7 | 38.4 | 50.6 |
NOTE. Data for 5 different cutoff values of EEsAI PRO score are shown. NPV, negative predictive value; PPV, positive predictive value.
a
Number of patients in endoscopic remission for a given EEsAI PRO score cutoff value.
b
Number of patients with a given EEsAI PRO score below the cutoff value.