Table 4.
Accuracy of Patient-Reported Clinical Symptoms (Assessed Using EEsAI PRO Score) to Detect Histologic Remission
| EEsAI PRO score cutoff | Cumulative remission,a n (%) | Cumulative frequency,b n (%) | PPV, % | NPV, % | Sensitivity, % | Specificity, % | Accuracy, % |
|---|---|---|---|---|---|---|---|
| Histologic remission: peak count of <20 eosinophils/mm2 | |||||||
| 15 | 38/96 (39.6) | 96/269 (35.7) | 39.6 | 78.6 | 50.7 | 70.1 | 64.7 |
| 20 | 42/111 (37.8) | 111/269 (41.3) | 37.8 | 79.1 | 56.0 | 64.4 | 62.1 |
| 25 | 42/112 (37.5) | 112/269 (41.6) | 37.5 | 79.0 | 56.0 | 63.9 | 61.7 |
| 30 | 51/162 (31.5) | 162/269 (60.2) | 31.5 | 77.6 | 68.0 | 42.8 | 49.8 |
| 35 | 54/180 (30.0) | 180/269 (66.9) | 30.0 | 76.4 | 72.0 | 35.1 | 45.4 |
| Histologic remission: peak count of <60 eosinophils/mm2 | |||||||
| 15 | 49/96 (51.0) | 96/269 (35.7) | 51.0 | 70.5 | 49.0 | 72.2 | 63.6 |
| 20 | 54/111 (48.6) | 111/269 (41.3) | 48.6 | 70.9 | 54.0 | 66.3 | 61.7 |
| 25 | 54/112 (48.2) | 112/269 (41.6) | 48.2 | 70.7 | 54.0 | 65.7 | 61.3 |
| 30 | 68/162 (42.0) | 162/269 (60.2) | 42.0 | 70.1 | 68.0 | 44.4 | 53.2 |
| 35 | 71/180 (39.4) | 180/269 (66.9) | 39.4 | 67.4 | 71.0 | 35.5 | 48.7 |
NOTE. Data for 5 different cutoff values of EEsAI PRO score are shown. NPV, negative predictive value; PPV, positive predictive value.
a
Number of patients in histologic remission for a given EEsAI PRO score cutoff value.
b
Number of patients with a given EEsAI PRO score below the cutoff value.