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. 2018 Jun 14;9:206. doi: 10.3389/fgene.2018.00206

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Copyright © 2018 Iuliano, Occhipinti, Angelini, De Feis and Liò.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration of mRNA data and CNAs profiles: BMD+DAD-screening network using Coxnet (top) and ADMMnet (bottom) methods with mRNA expression data and the integration of mRNA data and CNAs profiles. Non isolated genes are represented as nodes in the network, then a link a drawn between two (adjacent) genes when the two genes belong to the same KEGG pathway. We use different colors for KEGG pathways and three colors to identify the type gene: orange color for genes-HEFaIMp-high, green color for genes-HEFaIMp-low, purple color for genes-no-HEFaIMp. Triangular-shaped nodes indicate the genes identified in literature as breast-cancer associated genes. The number of papers is also reported in the triangular nodes.