Table 3.
Meta-analysis of CETP/LIPC/LPL/ABCA1/ABCG1 polymorphisms compared between PCV and AMD.
| Region | Gene | Polymorphism | Ethnicity | Associated versus reference allele | Number of cohorts | Sample size (PCV/AMD) | OR (95% CI) | Z score | P value | I 2 (%) | P value of Begg's test | P value of Egger's test |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 16q21 | CETP | rs3764261 | Chinese | T versus G | 3 | 774/587 | 1.17 (0.971–1.409) | 1.65 | 0.178 | 33.6 | >0.999 | 0.572 |
| 9q31 | ABCA1 | rs1883025 | Chinese | T versus C | 3 | 781/775 | 1.025 (0.869–1.208) | 0.29 | 0.77 | 0 | >0.999 | 0.832 |
| 9q31 | LIPC | rs493258 | Chinese | G versus A | 2 | 483/357 | 1.123 (0.897–1.407) | 1.01 | 0.312 | 0 | >0.999 | — |
| 15q22 | LIPC | rs10468017 | Chinese | T versus C | 3 | 774/587 | 1.101 (0.892–1.359) | 0.89 | 0.371 | 0 | 0.296 | 0.483 |
| 15q22 | LPL | rs12678919 | Asia | G versus A | 2 | 541/387 | 1.163 (0.861–1.572) | 0.98 | 0.325 | 0 | >0.999 | — |
| 21q22 | ABCG1 | rs57137919 | Asia | A versus G | 4 | 860/816 | 1.208 (1.035–1.411) | 2.39 | 0.017 | 0 | 0.734 | 0.156 |
| 16q21 | CETP | rs2303790 | Asia | G versus A | 5 | 1312/1314 | 1.067 (0.825–1.378) | 0.49 | 0.622 | 0 | 0.462 | 0.299 |
Summary of the genetic difference in CETP/LIPC/LPL/ABCA1/ABCG1 polymorphisms between PCV and AMD is shown. PCV: polypoidal choroidal vasculopathy; AMD: age-related macular degeneration; OR: odds ratio; CI: confidence interval.