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. 2018 May 27;2018:8736949. doi: 10.1155/2018/8736949

Figure 6.

Figure 6

CD38-mediated Sirt1/NF-κB/TLR2 signaling is NAD-dependent. The expressions of TLR2, NF-κB p65, and acetyl-p65 (Ac-p65) proteins were detected by Western blot (a) and quantitatively determined for TLR2 (b), NF-κB p65 (c) and NF-κB Ac-p65 (d) in control and CD38-overexpressed RAW264.7 cells in the absence or presence of NAD. GAPDH was used as an internal control. The data represent the mean ± S.D. from three independent experiments. ∗ p < 0.05 and ∗∗ p < 0.01 compared with the dCas9 group; # p < 0.05 and ## p < 0.01 compared with the CD38 group.