Table 13.

Summary of relative organ weights (organ weight relative to body weight) (%) in the 90-day repeated oral toxicity study.

Group (mg/kg bw/day)	Brain	Liver	Kidneys	Heart	Thymus	Spleen	Testes/uterus	Epididymides/ovaries	Adrenals	Thyroid
Male (main groups, n = 10 each)
Control	0.539 ± 0.028	2.515 ± 0.098	0.554 ± 0.036	0.284 ± 0.018	0.103 ± 0.021	0.165 ± 0.026	0.902 ± 0.051	0.441 ± 0.052	0.018 ± 0.002	0.006 ± 0.002
100	0.545 ± 0.054	2.595 ± 0.081	0.570 ± 0.040	0.281 ± 0.034	0.094 ± 0.012	0.157 ± 0.011	0.933 ± 0.054	0.426 ± 0.038	0.019 ± 0.003	0.005 ± 0.002
360	0.581 ± 0.043	3.196 ± 0.147∗∗	0.591 ± 0.044∗	0.272 ± 0.019	0.090 ± 0.024	0.158 ± 0.025	0.938 ± 0.086	0.430 ± 0.049	0.023 ± 0.004∗∗	0.006 ± 0.001
720	0.617 ± 0.055∗∗	4.093 ± 0.228∗∗	0.631 ± 0.027∗∗	0.290 ± 0.028	0.088 ± 0.020	0.168 ± 0.021	1.002 ± 0.080∗∗	0.414 ± 0.026	0.024 ± 0.004∗∗	0.007 ± 0.002
Historical range♮	0.441–0.599	1.916–3.108	0.466–0.650	0.216–0.311	0.057–0.191	0.058–0.219	0.642–1.011	0.320–0.512	0.012–0.023	0.0037–0.0089
Male (recovery group, n = 5 each)
Control	0.478 ± 0.015	2.454 ± 0.089	0.522 ± 0.019	0.236 ± 0.015	0.087 ± 0.015	0.158 ± 0.019	0.806 ± 0.014	0.418 ± 0.027	0.017 ± 0.002	0.006 ± 0.000
720	0.550 ± 0.032∗∗	2.392 ± 0.158	0.587 ± 0.037∗∗	0.265 ± 0.020∗	0.098 ± 0.021	0.168 ± 0.023	0.941 ± 0.082∗∗	0.460 ± 0.032	0.017 ± 0.001	0.007 ± 0.000∗∗
Female (main groups, n = 10 each)
Control	0.825 ± 0.028	2.693 ± 0.174	0.625 ± 0.040	0.322 ± 0.022	0.128 ± 0.018	0.230 ± 0.034	0.327 ± 0.088	0.0669 ± 0.0110	0.0348 ± 0.0043	0.0096 ± 0.0022
100	0.805 ± 0.072	2.854 ± 0.133	0.609 ± 0.024	0.324 ± 0.027	0.159 ± 0.024∗∗	0.196 ± 0.023∗∗	0.251 ± 0.051∗	0.0616 ± 0.0162	0.0357 ± 0.0051	0.0083 ± 0.0018
360	0.853 ± 0.094	3.298 ± 0.144∗∗	0.598 ± 0.034	0.317 ± 0.033	0.145 ± 0.026	0.191 ± 0.023∗∗	0.224 ± 0.094∗∗	0.0627 ± 0.0108	0.0413 ± 0.0054∗	0.0091 ± 0.0027
720	0.882 ± 0.055∗	4.322 ± 0.281∗∗	0.637 ± 0.038	0.323 ± 0.025	0.141 ± 0.017	0.169 ± 0.018∗∗	0.215 ± 0.055∗∗	0.0653 ± 0.0163	0.0469 ± 0.0068∗∗	0.0109 ± 0.0037
Historical range♮	0.681–0.943	2.172–3.214	0.530–0.752	0.273–0.396	0.093–0.217	0.140–0.298	0.167–0.852	0.043–0.086	0.026–0.044	0.0052–0.0128
Female (recovery group, n = 5 each)
Control	0.820 ± 0.023	2.671 ± 0.167	0.633 ± 0.032	0.299 ± 0.012	0.151 ± 0.020	0.196 ± 0.020	0.290 ± 0.045	0.0562 ± 0.0137	0.0285 ± 0.0031	0.0090 ± 0.0004
720	0.885 ± 0.043∗	2.700 ± 0.064	0.629 ± 0.014	0.309 ± 0.016	0.152 ± 0.008	0.197 ± 0.023	0.221 ± 0.047∗	0.0600 ± 0.0136	0.0345 ± 0.0027∗	0.0109 ± 0.0010∗∗

Data represent the mean values and the standard deviation.

∗P < 0.05 and ∗∗P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney U test versus control.

♮: minimum and maximum levels reported as the range of historical control values.