Table 14.

Summary of relative organ weights (organ and body weight relative to brain weight) (%) in the 90-day repeated oral toxicity study.

Group (mg/kg bw/day)	Body weight	Liver	Kidneys	Heart	Thymus	Spleen	Testes/uterus	Epididymides/ovaries	Adrenals	Thyroid
Male (main groups, n = 10 each)
Control	18591.6 ± 968.39	468.24 ± 40.18	102.89 ± 6.65	52.69 ± 3.69	19.15 ± 3.63	30.70 ± 4.40	167.49 ± 8.20	81.70 ± 8.27	3.31 ± 0.39	1.09 ± 0.28
100	18490.1 ± 1785.06	479.69 ± 46.21	105.21 ± 11.56	51.68 ± 5.97	17.48 ± 3.71	28.94 ± 3.10	172.03 ± 13.70	78.46 ± 6.78	3.57 ± 0.45	1.01 ± 0.34
360	17293.5 ± 1365.76	552.65 ± 49.26∗∗	102.35 ± 11.99	46.98 ± 5.17∗	15.64 ± 4.23	27.28 ± 4.46	161.87 ± 16.34	74.05 ± 7.67∗	4.02 ± 0.61∗∗	1.11 ± 0.22
720	16340.7 ± 1594.47∗∗	670.06 ± 90.43∗∗	103.09 ± 10.65	47.16 ± 3.98∗	14.29 ± 3.43∗	27.46 ± 4.11	163.26 ± 16.05	67.57 ± 6.46∗∗	3.96 ± 0.50∗∗	1.14 ± 0.25
Historical range♮	16681–22689	371.50–660.20	91.59–131.25	43.53–65.22	10.45–38.18	11.82–41.71	129.65–186.05	63.76–98.40	2.19–4.32	0.78–1.80
Male (recovery group, n = 5 each)
Control	20923.4 ± 682.77	513.36 ± 19.85	109.06 ± 3.33	49.28 ± 2.09	18.12 ± 3.19	32.97 ± 3.96	168.56 ± 3.71	87.37 ± 4.30	3.44 ± 0.34	1.19 ± 0.07
720	18234.7 ± 1067.39∗∗	435.79 ± 31.87∗∗	106.81 ± 1.71	48.18 ± 2.34	17.79 ± 3.54	30.55 ± 3.78	171.55 ± 16.96	83.77 ± 5.21	3.07 ± 0.23	1.25 ± 0.14
Female (main groups, n = 10 each)
Control	12135.2 ± 419.40	326.63 ± 20.94	75.83 ± 6.20	39.04 ± 3.11	15.47 ± 2.16	27.91 ± 3.98	39.68 ± 10.63	8.11 ± 1.30	4.22 ± 0.51	1.16 ± 0.27
100	12513.6 ± 1162.30	357.88 ± 44.84	76.19 ± 6.93	40.48 ± 4.55	19.89 ± 3.29∗∗	24.50 ± 3.34∗	31.50 ± 6.98	7.74 ± 2.23	4.50 ± 0.95	1.04 ± 0.25
360	11848.4 ± 1337.88	391.14 ± 50.90∗∗	70.90 ± 9.89	37.63 ± 6.71	17.29 ± 4.20	22.74 ± 4.47∗∗	26.75 ± 12.08∗∗	7.46 ± 1.70	4.89 ± 0.79	1.06 ± 0.23
720	11377.7 ± 735.76∗	490.87 ± 33.83∗∗	72.47 ± 6.17	36.65 ± 3.17	15.97 ± 2.06	19.19 ± 2.33∗∗	24.65 ± 6.98∗∗	7.41 ± 1.83	5.32 ± 0.70∗∗	1.24 ± 0.44
Historical range♮	10600.0–14685.7	276.04–412.95	65.08–104.71	33.65–49.74	11.82–27.55	17.84–38.34	18.96–99.52	5.19–10.79	3.12–5.49	0.65–1.53
Female (recovery group, n = 5 each)
Control	12200.5 ± 339.93	325.87 ± 21.65	77.26 ± 4.22	36.44 ± 2.25	18.49 ± 2.75	23.86 ± 1.79	35.34 ± 4.81	6.84 ± 1.58	3.47 ± 0.38	1.10 ± 0.06
720	11316.1 ± 560.61∗	305.45 ± 14.34	71.15 ± 3.85∗	35.03 ± 2.81	17.19 ± 1.42	22.18 ± 1.86	24.95 ± 5.06∗	6.78 ± 1.55	3.90 ± 0.25	1.23 ± 0.11

Data represent the mean values and the standard deviation.

∗P < 0.05 and ∗∗P < 0.01, statistical significances were determined with Duncan's multiple range test or with Mann–Whitney U test versus control.

♮: minimum and maximum levels reported as the range of historical control values.