Table 3.

Summary of chromosomal aberration test results.

Concentration	S9 mix	Treatment	Harvest	Mean aberrant cells (per 200 cells)		Number of aberrations
μg/mL		Time (h)	Time(h)	Incl. gaps	Excl. gaps	Incl. gaps	Excl. gaps
	Experiment A 1
Test Article
10	–	3	20	7	4	7	4
20	–	3	20	6	3	8	3
30	–	3	20	7	4	8	4
Vehicle control	–	3	20	6	3	6	3
Positive control	–	3	20	60∗∗	48∗∗	100∗∗	63∗∗
Hist. veh. control4	–	3	20	0.35–11.99	0.00–7.30	n/a	n/a
Test Article
50	+	3	20	8	5	9	5
70	+	3	20	7	3	7	3
90	+	3	20	9	5	10	5
Vehicle control	+	3	20	7	4	7	3
Positive control	+	3	20	69∗∗	58∗∗	130∗∗	85∗∗
Hist. veh. control4	+	3	20	0.00–15.19	0.53–5.47	n/a	n/a
	Experiment B 2
Test Article
1.25	–	20	20	6	2	6	2
2.5	–	20	20	6	3	6	3
5	–	20	20	8	3	8	3
Vehicle control	–	20	20	6	3	7	3
Positive control	–	20	20	55∗∗	48∗∗	112∗∗	60∗∗
Hist. veh. control4	–	20	20	2.58–10.42	1.39–4.94	n/a	n/a
	Experiment B 3
Test Article
1.25	–	20	28	8	4	8	4
2.5	–	20	28	7	4	8	4
5	–	20	28	8	4	8	4
Vehicle control	–	20	28	6	3	6	3
Positive control	–	20	28	67∗∗	62∗∗	146∗∗	84∗∗
Hist. veh. control4	–	20	28	2.70–11.30	3.00–3.00	n/a	n/a
Test Article
50	+	3	28	9	4	10	5
70	+	3	28	9	4	10	4
90	+	3	28	7	3	8	4
Vehicle control	+	3	28	7	4	7	4
Positive control	+	3	28	63∗∗	54∗∗	140∗∗	105∗∗
Hist. veh. control4	+	3	28	4.73–8.27	0.00–6.97	n/a	n/a

¹Positive controls: (–S9): ethyl methanesulfonate (1.0 μL/mL); (+S9): cyclophosphamide (5.0 μg/mL).

²Positive control: (–S9): ethyl methanesulfonate (0.4 μL/mL).

³Positive controls: (–S9) ethyl methanesulfonate (0.4 μL/mL); (+S9): cyclophosphamide (5.0 μg/mL).

⁴Numbers reported are the 95% confidence interval.

∗∗p < 0.01 to the concurrent vehicle control and to the historical vehicle control.

n/a, not available; veh., vehicle; Hist., historical; Incl., including; Excl., excluding.