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. 2001 Oct 23;98(22):12665–12670. doi: 10.1073/pnas.211443698

Table 3.

Common genes, responding to irradiation in U87 and HEL cell lines and U87 xenografts

Access. no. Group and name U87-C
HEL-C
U87-X
Comments
1 Gy 3 Gy 10 Gy 1 Gy 3 Gy 10 Gy 1 Gy 3 Gy 10 Gy
1. Homeostasis/self defense
AA464246 HLA-C 1.28 1.20 0.51 0.98 0.91 2.65 1.71 1.74 1.53 ↓ D
AA434117 HLA-B-assot. G9a 0.89 0.57 0.51 0.72 0.78 0.61 $
AA670408 β2-Microglobulin 1.02 2.14 0.53 1.43 1.82 5.78 1.80 1.93 1.24 $ * D
AA778663 4-1BB ligand 1.67 1.38 0.35 4.43 10.70 12.1 * A
AA136271 CD58 (LFA3) 1.06 0.89 0.20 0.51 0.90 0.59 $
R77293 ICAM1 1.22 0.99 0.42 2.00 1.47 2.46 ↓ B
AA130584 CEACAM5 1.77 1.28 1.88 3.22 18.63 3.64 * A
N51018 Biglycan 1.33 1.22 1.64 0.47 0.74 1.69 * E
AA399674 SPRR2C 0.85 0.89 0.43 0.82 0.84 1.79
T49657 K+ channel TASK 2.09 1.61 2.36 1.60 1.89 1.68 4.62 3.90 5.36 $ * A
AA069770 K+ channel KCNB1 0.56 1.53 1.59 10.07 7.12 6.79 ↓ C
H14808 Na+/K+ ATPase β2 1.46 0.93 2.11 3.07 2.43 6.45 * A
H24316 Aquaporin 1.03 1.63 1.44 24.56 12.25 5.84 * C
H57136 PLM Cl channel 1.23 1.80 1.60 0.87 0.84 0.53 2.72 4.17 4.44 * C
AA402891 Transporter ENT2 1.08 1.19 1.60 6.07 36.08 2.61 * C
AA191488 Cu2+ uptake protein CTR1 1.72 1.00 2.46 2.42 3.20 4.39 1.05 1.27 1.80 $ * E
AA490459 Transcobalamin II 0.76 0.61 0.55 0.47 0.83 0.31 $
H72723 MT1B 1.12 0.61 0.57 2.04 2.93 5.46 ↓ D
H23187 Carbonic anhydrase II 0.84 1.10 0.59 4.41 2.50 2.26 ↓B
2. Cell–cell communications/signaling
R56211 PDGFRβ 1.02 1.12 1.87 0.92 1.37 1.85 $
AA486393 IL-10 receptor β 1.72 1.19 1.60 6.12 3.84 3.78 * A
AA485226 Vitamin D receptor 2.31 0.69 0.64 6.54 9.35 3.34 * A
H54023 MIR-10 (LILRB2) 1.71 1.00 1.35 0.48 0.63 1.98 ↓ E
AA400973 Lipocalin 2 1.16 0.56 0.49 0.68 0.62 0.53 $
AA485922 Copine I 1.65 1.06 1.08 3.84 3.74 4.24 * A
R73545 Flotillin 2 1.18 0.94 0.61 1.11 1.17 1.89
N20203 BMP receptor II 0.60 0.79 0.97 5.54 2.88 2.00 ↓ B
AA450062 BMP, placental 1.45 1.49 1.60 1.35 0.82 1.62 $
AA489383 BMP 2 1.71 1.61 1.80 0.61 2.14 1.61 1.77 1.69 1.06 $ * F
T55558 CSF 1 0.92 1.29 0.56 0.83 0.61 0.52 $
AA486072 RANTES 1.14 0.67 0.42 4.92 2.79 3.74 ↓ A
R43320 G-protein GNAO1 1.79 1.05 1.83 0.61 0.82 1.65 * E
R56046 G-protein GNAZ 0.74 0.87 0.49 0.85 0.93 1.77 0.73 0.67 1.75 ↓ E
AA458785 Guanylate cyclase β1 1.74 1.45 1.86 3.89 3.75 4.07 * A
R37953 Adenylyl cyclase associated protein 1.31 1.23 0.59 1.04 1.04 2.60
N28497 PP2A (PPP2R1B) 1.16 1.35 2.00 0.78 0.77 0.33 7.81 6.84 5.31 * B
H15718 Protein kinase AXL 0.76 0.59 0.80 0.48 0.57 0.52 $
AA453789 Protein kinase 7 0.94 1.19 0.60 0.69 1.04 0.53 $
R59598 Protein kinase Syk 0.56 0.64 0.48 0.54 0.61 0.76 $
R80779 Protein kinase MLK-3 1.15 1.50 1.66 10.99 6.73 4.43 * B
AA890663 Protein kinase PAK1 0.64 1.95 1.80 0.90 1.06 0.56
N52958 SLP-76 1.38 2.21 1.72 1.07 1.32 1.80 *
H73724 CDK6 1.76 1.53 2.08 0.47 0.81 2.01 *E
AA464731 Calgizzarin 1.01 0.96 0.33 1.06 1.07 2.35
N63940 Acetylcholinesterase 0.83 0.61 0.87 0.65 0.62 0.84 $
3. Cytoskeleton/motility
AA703141 Protein 4.1 (EBP41) 0.60 0.63 0.64 0.61 0.81 1.34 $
AA877166 Myosin light chain 2 0.83 1.01 0.57 0.83 0.86 0.49 $
AA504625 Kinesin heavy chain 0.62 1.34 0.59 4.42 12.29 0.25 * C
AA868929 Troponin T1 1.01 0.53 0.27 0.18 0.12 1.98 *
R44290 β-Actin (ACTB) 1.13 0.60 0.55 1.32 1.47 3.48 1.79 1.93 1.43 ↓ D
AA634006 Actin α-2 (ACTSA) 1.51 0.80 0.51 1.01 1.30 3.16 1.55 1.55 1.52 ↓ D
AA629189 Keratin 4 (KRT4) 1.08 1.08 1.62 1.02 1.32 0.39
4. RNA synthesis/modifications
H99588 LAF4 3.15 1.23 2.62 3.62 2.70 4.83 0.59 0.82 1.65 $ * E
N47099 SMAD2 1.12 1.64 2.04 0.94 1.90 0.55 $
AA478268 CTBP 1 1.17 1.63 1.44 3.99 5.34 2.77 * B
AA394127 NF-AT3 1.24 0.96 0.36 1.15 0.90 2.19
AA258001 RELB 1.02 1.10 0.59 5.12 7.57 2.33 ↓ C
AA253434 Transcription factor HSF2 1.08 0.60 1.06 5.09 2.64 1.86 ↓ C
AA457155 ZNF212 0.49 0.68 1.32 2.02 0.87 2.45
R02346 U1 snRNP 70 2.57 1.32 2.59 1.33 1.51 1.98 6.29 5.46 8.60 $* A
AA496879 RNP S1 1.58 1.70 2.43 1.18 1.02 0.47 7.72 7.05 4.26 $* B
N26026 Gemin 2 (SIP1) 2.31 2.94 3.88 5.00 4.38 3.32 * A
AA126911 hnRNP A1 0.99 0.57 0.39 1.65 1.81 4.53
AA431440 hnRNP-E2 0.81 0.64 0.61 0.83 1.09 2.01
T60163 RNase L 1.13 1.09 1.64 6.84 8.45 3.32 * B
5. Protein synthesis/modifications
R43973 EF1γ 2.23 1.22 0.54 1.69 1.30 3.83 $
R54097 elF-2b 0.91 0.63 0.50 0.55 0.98 2.15
AA873351 RP L35a 0.97 2.30 1.61 0.93 0.91 2.28 1.91 1.67 1.34 $* D
T69468 RPS4Y 0.51 1.01 0.89 1.95 1.87 3.26
AA490011 RPL38 1.43 0.92 0.22 0.99 1.40 2.97
T67270 RPL10 1.97 1.29 0.61 1.22 1.31 2.75
AA464743 RPL21 1.09 1.31 0.52 0.87 0.91 1.73
AA680244 RPL11 1.01 1.18 0.25 0.84 1.18 2.94
W96450 aa-tRNA synthetase FARSL 1.10 1.67 1.46 1.97 1.84 1.36 * F
AA599158 aa-tRNA synthetase EPRS 0.97 0.89 0.56 2.20 1.84 1.31 ↓ F
AA664241 α-NAC 0.60 0.83 2.07 0.89 1.09 1.68 $
AA424786 Golgin-95 0.90 0.99 0.57 10.02 19.14 2.95 ↓ C
AA457114 Protein B94 1.85 1.14 1.95 4.01 2.33 6.45 * D
AA504455 LDLC 1.71 1.92 1.62 2.43 1.88 1.50 * F
R78585 Calumenin 0.99 1.02 0.53 1.02 1.26 2.89 1.06 1.44 1.14 ↓D
T71316 ADP-ribosylation factor 4 1.25 0.79 0.48 0.94 1.05 3.12
AA455301 Protein GPAA1 0.58 0.58 0.93 2.43 2.11 1.57 ↓ B
N78843 CYP-33 (PPIE) 1.79 1.47 1.69 8.57 5.27 3.85 * C
H98666 PCOLN3 0.80 0.60 0.50 0.78 0.61 0.60 $
AA430524 ACE 1.17 1.70 1.99 1.78 2.85 1.66 * A
AA410517 Serpin PTI 0.91 1.47 1.79 1.31 1.60 2.72 $
W61361 Serpin CAP2 1.24 1.76 1.27 6.67 8.93 3.52 * C
AA430512 Serpin CAP3 1.22 1.53 1.69 6.45 5.37 4.20 * B
AA402874 Protective protein 1.15 0.76 0.55 1.20 1.21 1.42 ↓ D
6 & 8. Metabolism/energy/oxidative stress
N33331 PPARδ 1.15 1.62 1.45 34.35 50.10 95.30 * C
AA465366 Leukotriene A4 hydrolase 1.69 2.28 0.85 4.58 7.54 3.17 * C
R55046 MpV17 (peroxisome) 0.75 0.60 0.57 1.30 1.69 2.18
W49667 Fatty acid desaturase 1.08 0.43 1.08 4.36 4.38 3.79 ↓ A
W95082 11β-hydroxysteroid dehydrogenase 1.07 0.80 0.45 0.45 0.82 0.44 16.25 5.88 3.48 $ B
T73294 P450 reductase 1.78 1.05 2.01 0.80 0.71 2.69 *
AA708298 H+ ATP synthase 1.20 1.02 0.49 1.11 1.62 5.38 1.85 1.46 1.30 ↓D
H61243 Uncoupling protein 2 0.93 0.82 0.53 1.07 0.93 1.81
W96179 Glutamate-cysteine ligase 2.67 2.03 3.18 6.69 4.97 4.54 * A
AA463458 Glutathione synthetase 0.94 0.73 0.32 1.73 0.94 1.43
AA290738 GSTM4 1.10 0.93 0.46 4.34 2.92 2.00 ↓ B
R52548 SOD-1 0.92 0.84 0.60 6.58 3.01 2.12 ↓ B
R39463 Aldolase C 0.98 0.90 0.58 0.62 0.77 0.47 $
H05914 LDHA 0.84 1.27 0.59 1.15 1.12 2.68
AA629567 HSP73 1.07 0.86 0.49 1.00 1.39 2.40
7. DNA metabolism/chromatin structure
H15112 Uracil-DNA glycosylase 1 0.45 0.58 1.64 0.85 1.36 1.70 $
N26769 DNA glycosylase (MPG) 0.89 0.94 0.55 5.88 3.06 1.70 ↓B
AA608557 XPE1 (DDB1) 1.61 1.16 1.98 0.68 0.77 1.76 * E
AA035095 BCR protein 1 0.99 0.74 0.52 0.65 0.93 0.54 $
AA460927 Translin 0.53 1.29 2.49 0.99 1.51 2.37 $
AA442991 Prothymosin α (PTMA) 2.56 2.01 1.06 2.19 1.61 2.66 $
AA456077 Centromere protein p27 0.86 0.72 0.44 0.62 0.88 0.41 $
R56871 Chromatin assembly factor-I 0.69 0.98 1.82 0.94 0.30 0.60
9. Unclassified
AA683321 PAR-5 1.72 1.27 1.38 2.26 2.62 8.38 0.44 0.72 1.61 ↓ $ E
R06254 Protein D54 1.62 0.92 1.68 1.26 1.29 1.87 $
AA406064 BPY1 1.78 1.86 2.12 1.68 2.57 1.02 * D
AA448289 Protein D123 1.14 1.05 2.08 9.12 10.66 9.06 * C
N34095 FEZ2 1.14 1.55 1.69 2.86 3.20 3.70 * A
R87497 2.19 gene 1.85 2.70 1.71 4.32 3.50 5.08 * A
AA452826 Purkinje cell protein 4 0.60 0.80 0.59 5.26 3.82 3.32 ↓ D

Genes that responded to irradiation in both U87 and HEL cell lines in vitro or U87 grown in cell culture (U87-C) or transplanted in xenografts (U87-X) are shown. Genes distributed according cell functions. Numbers are average ratios of significant up- or down-regulation for each dose tested at 5 h after irradiation. $, consistent up- or down-regulation in both U87 and HEL in vitro

*

, consistent up- or down-regulation in both U87 in vitro and U87 xenografts; ⇅, opposite response in either U87/HEL or U87-C/U87-X cell types; A–F, cluster of expression in U87 xenografts (see Fig. 1). 

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