Figure 6.

Apoptotic activities of Manilkara zapota leaf methanol extract on HeLa cells after 72 h incubation. HeLa cells treated with 12 and 48 μg/mL of Manilkara zapota leaf methanol extract upregulated apoptotic protein expression of (a) Bax and downregulated (b) Bcl-2, respectively. (c) Manilkara zapota leaf methanol extract-induced caspase-3 activation. Values are reported as mean ± SD (n = 3). Value with different superscript letter indicates significant difference between groups by Tukey's test (P < 0.05).