Table 1.
Lipid profiles of Wt, L−/−, A−/−, and L−/−/A−/− mice.
| L −/−/A−/− | L −/−/A−/− | Wt | L −/− | A −/− | L −/−/A−/− | L −/−/A−/− | L −/−/A−/− | L −/−/A−/− | L −/−/A−/− | |
|---|---|---|---|---|---|---|---|---|---|---|
| Age (weeks) | 12 | 18 | 24 | 24 | 24 | 24 | 36 | 48 | 60 | 72 |
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| Na | 14 | 16 | 17 | 14 | 11 | 45 | 38 | 26 | 13 | 17 |
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| Body weight (g) | 26.3 ± 1.6 | 27.4 ± 2.1 | 28.7 ± 2.7 | 28.4 ± 2.4 | 31.7 ± 3.0 | 29.0 ± 2.4 | 29.3 ± 3.0 | 32.8 ± 3.2 | 34.5 ± 4.1 | 31.8 ± 2.3 |
|
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| Total-Cb (mg/dL) | 341 ± 68 | 347 ± 66 | 66.6 ± 8.3 | 255.1 ± 45.5 | 74.6 ± 13.2 | 350 ± 79 | 337 ± 96 | 348 ± 64 | 335 ± 30 | 325 ± 77 |
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| VLDL-Cc (mg/dL) | 22.8 ± 10.8 | 23.3 ± 5.5 | NA | 20.0 ± 7.4 | NA | 36.1 ± 10.3 | 21.4 ± 7.8 | 29.6 ± 11.3 | 21.1 ± 9.2 | 19.8 ± 9.8 |
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| LDL-Cd (mg/dL) | 275 ± 60 | 268 ± 57 | NA | 163.2 ± 19.9 | NA | 264 ± 50 | 267 ± 84 | 274 ± 51 | 271 ± 23 | 271 ± 67 |
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| HDL-Ce (mg/dL) | 44.1 ± 8.0 | 49.4 ± 9.1 | NA | 97.0 ± 26.1 | NA | 47.4 ± 16.1 | 43.8 ± 13.4 | 40.2 ± 12.2 | 36.2 ± 4.9 | 33.5 ± 11.6 |
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| LDL-C/HDL-C | 6.4 ± 1.7 | 5.5 ± 0.7 | NA | 1.8 ± 0.6 | NA | 6.2 ± 2.6 | 6.3 ± 1.9 | 7.2 ± 1.7 | 7.3 ± 1.4 | 8.5 ± 2.0 |
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| Triglyceride (mg/dL) | 168 ± 33 | 155 ± 22 | 63.4 ± 20.3 | 102.6 ± 28.8 | 75.4 ± 21.6 | 154 ± 28 | 153 ± 33 | 159 ± 25 | 157 ± 28 | 120 ± 22 |
aNumber of mice used at each age.
bTotal cholesterol.
cCholesterol contained in VLDL.
dCholesterol contained in LDL.
eCholesterol contained in HDL.