Table 2.
Formulation composition of miconazole nitrate-loaded SLMs.
| Batch code | Lipid matrix (%w/w) |
Miconazole nitrate (%w/w) |
Tween® 80 (%w/w) |
Soluplus® (%w/w) |
Sorbic acid (%w/w) |
Distilled water q.s. to 100 %w/w |
|---|---|---|---|---|---|---|
| AM1 | 10.0 | 1.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| BM1 | 10.0 | 1.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| CM1 | 10.0 | 1.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| DM1 | 10.0 | 1.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| AM2 | 10.0 | 2.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| BM2 | 10.0 | 2.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| CM2 | 10.0 | 2.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| DM2 | 10.0 | 2.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| AM3 | 10.0 | 3.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| BM3 | 10.0 | 3.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| CM3 | 10.0 | 3.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| DM3 | 10.0 | 3.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| A0 | 10.0 | 0.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| B0 | 10.0 | 0.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| C0 | 10.0 | 0.0 | 1.0 | 4.0 | 0.1 | 100.0 |
| D0 | 10.0 | 0.0 | 1.0 | 4.0 | 0.1 | 100.0 |
Key: batches (A0, AM1–AM3) are non-PEGylated SLMs; batches B, C, and D are PEGylated SLMs containing increasing concentrations (1.0, 2.0, and 4.0 %w/w) of PEG 4000, respectively; A0–D0 are unloaded SLMs while batches AM1–DM1, AM2–DM2, and AM3–DM3 contain increasing concentrations (1.0, 2.0, and 3.0 %w/w) of miconazole nitrate, respectively.