Table 3.
Thermal properties of the lipid matrices for SLMs preparation.
Sample | Melting point (°C) |
Enthalpy (W/g) | Melting temperature range (°C) | Area (J/g) |
---|---|---|---|---|
Softisan® 154 | 61.40 | - 8.9 | 37 – 75 | 71.92 |
LM 1:1 | 60.82 | - 9.0 | 25 – 75 | 271.5 |
LM 1:3 | 61.62 | - 2.5 | 25 – 75 | 61.19 |
LM 1:6 | 115.18 | - 0.25 | 110 – 127 | 4.228 |
LM 1:9 | 64.56 | - 2.05 | 25 – 75 | 47.63 |
PEG 4000 | 64.40 | - 3.6 | 50 – 75 | 67.20 |
PEG-LM1:1 (1:9) | 142.49 | - 0.35 | 135 – 157 | 33.24 |
PEG-LM1:1 (2:8) | 145.66 | - 0.4 | 142 – 148 | 47.18 |
PEG-LM1:1 (4:6) | 62.66 | - 2.0 | 25 – 75 | 64.87 |
PEG-LM1:3 (1:9) | 88.00 | - 0.35 | 80 – 115 | 25.35 |
PEG-LM1:3 (2:8) | 60.60 | - 3.4 | 45 – 70 | 39.89 |
PEG-LM1:3 (4:6) | 65.76 | - 2.3 | 25 – 75 | 53.63 |
PEG-LM1:6 (1:9) | 61.51 | - 4.0 | 37 – 75 | 84.55 |
PEG-LM1:6 (2:8) | 61.57 | - 3.25 | 25 – 75 | 52.22 |
PEG-LM1:6 (4:6) | 61.75 | - 4.5 | 25 – 75 | 99.11 |
PEG-LM1:9 (1:9) | 60.75 | - 4.25 | 25 – 75 | 72.59 |
PEG-LM1:9 (2:8) | 61.32 | - 3.6 | 25 – 75 | 60.29 |
PEG-LM1:9 (4:6) | 61.12 | - 4.1 | 25 – 75 | 68.82 |
Key: LM 1:1, LM 1:3, LM 1:6, and LM 1:9 are non-PEGylated lipid matrices containing increasing amounts of Softisan® 154; PEG-LM 1:1(1:9), PEG-LM 1:1(2:8), and PEG-LM 1:1(4:6) are PEGylated lipid matrices based on 1:1 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000; PEG-LM 1:3(1:9), PEG-LM 1:3(2:8), and PEG-LM 1:3(4:6) are PEGylated lipid matrices based on 1:3 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000; PEG-LM 1:6(1:9), PEG-LM 1:6(2:8), and PEG-LM 1:6(4:6) are PEGylated lipid matrices based on 1:6 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000, while PEG-LM 1:9(1:9), PEG-LM 1:9(2:8), and PEG-LM 1:9(4:6) are PEGylated lipid matrices based on 1:9 ratio of sunseed oil and Softisan® 154 and containing increasing amounts (10, 20, and 40 %w/w) of PEG 4000.