Table 5.
MICs and MFCs of optimized miconazole nitrate-loaded SLMs.
| Formulation code | MIC (μg/ml) | MFC (μg/ml) |
|---|---|---|
| AM3 | 29.297 ± 2.65 | 468.754 ± 5.06 |
| BM3 | 14.648 ± 0.98 | 234.375 ± 4.33 |
| CM3 | 7.324 ± 1.32 | 117.188 ± 2.19 |
| DM3 | 14.648 ± 3.08 | 234.375 ± 4.25 |
| MN pure sample suspension | 58.594 ± 4.11 | 937.500 ± 3.11 |
| Fungusol® lotion | 29.297 ± 2.22 | 468.754 ± 6.00 |
Key: MIC and MFC are minimum inhibitory concentration and minimum fungicidal concentration; AM3 is optimized non-PEGylated SLMs containing 3.0 %w/w of miconazole nitrate; BM3–DM3 are PEGylated SLMs containing increasing concentrations (1.0, 2.0, and 4.0 %w/w) of PEG 4000, respectively, and 3.0 %w/w of miconazole nitrate; Fungusol® is commercial topical formulation of miconazole nitrate, while MN is pure miconazole nitrate sample.