Table 6.
Cell killing parameters of optimized miconazole nitrate-loaded SLMs.
| Formulation code | Death rate constant, K (min−1) | D-value (min) |
|---|---|---|
| AM3 | 7.10 x 10−3 | 120.000 |
| BM3 | 8.80 x 10−3 | 105.541 |
| CM3 | 1.09 x 10−2 | 81.026 |
| DM3 | 1.09 x 10−2 | 81.026 |
| Fungusol® lotion | 8.00 x 10−3 | 109.389 |
| MN pure sample suspension | 5.60 x 10−3 | 164.835 |
Key: AM3 is optimized non-PEGylated SLMs containing 3.0 %w/w of miconazole nitrate; BM3–DM3 are PEGylated SLMs containing increasing concentrations (1.0, 2.0, and 4.0 %w/w) of PEG 4000, respectively, and 3.0 %w/w of miconazole nitrate; Fungusol® is commercial topical formulation of miconazole nitrate, while MN is pure miconazole nitrate sample.