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. 2018 May 24;90(12):7349–7356. doi: 10.1021/acs.analchem.8b00650

Figure 3.

Figure 3

Schematic of one-carbon cycle showing the connection between folate metabolism and methionine cycle (Scheme adapted from ref (21). Copyright Elsevier 2013). Color coding: purple, C1 donors; green, folates; blue, products of C1 metabolism and downstream pathways; white, not covered by method. Abbreviations: CTH, cystathionine γ-lyase; CBS, cystathionine β-synthase; DHF, dihydrofolate; FA, folic acid; Hcy, homocysteine; MAT, methionine adenosyltransferase; MS, methionine synthase; MTHFR, methylenetetrahydrofolate reductase; 5-MTHF, 5-methyl-tetrahydrofolate; MT, methyltransferase; SAH, S-adenosylhomocysteine; SAHH, SAH hydrolase; SAM, S-adenosylmethionine; SHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; B6, vitamin B6; B12, vitamin B12.