Figure 7.

Influence of the Gilbert's polymorphism on serum bilirubin levels in HIV-infected patients treated with indinavir. (Upper) Serum total bilirubin concentrations for individual patients with UGT1A1 promoter genotype 6/6 (dark circles), 6/7 (gray squares), and 7/7 (gray triangles) before (pre) and after (post) receiving a minimum of 4 weeks of oral indinavir. (Lower) The change in serum bilirubin concentration for each patient following indinavir treatment is stratified for the absence (6/6, dark circles) or presence (6/7, dark squares; or 7/7, gray triangles) of the Gilbert's mutation. Mean values for each group (solid lines) were 0.34 ± 0.29 mg/dl and 1.45 ± 0.99 mg/dl (±SD), respectively (P = 0.030).