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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Vet Immunol Immunopathol. 2018 May 21;201:49–56. doi: 10.1016/j.vetimm.2018.05.008

Table 1.

Summary of key inflammasome components. Note that representative activators are listed, and an exhaustive list is not provided. Abbreviations are based on those in the review by Jha and Ting (2009).

Abbreviation Full name Description Examples of Activators
Caspase-1 Protease
Caspase-11 Protease
ASC Apoptosis associated speck-like protein containing a caspase recruitment domain Adaptor/Scaffold
NLRC4 NLR family, CARD-containing (inflammasome)-4 Adaptor/Scaffold
NLRP1 NLR family, pyrin domain-containing (inflammasome)-1 Sensor Rodent: Anthrax lethal toxin, Toxoplasma gondii, depletion of cytosolic ATP
NLRP3 NLR family, pyrin domain-containing (inflammasome)-3 Sensor ATP, pore-forming toxins, crystalline matter
AIM2 Absent in melanoma-2 Sensor Double-stranded DNA, from host, viruses (e.g., vaccinia) or intracellular bacteria (e.g., Francisella tularensis novicida)
NAIPs (various) NLR apoptosis inhibitory protein Sensor Bacterial flagellin, and Type III secretion system components