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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Xenotransplantation. 2018 May;25(3):e12417. doi: 10.1111/xen.12417

Figure 2. Contribution of Nabs to transplantation and unanswered questions.

Figure 2

Innate polyreactive B cells undergo CSR in inflammatory conditions and produce IgG Nabs contributing to serum reactivity, kidney graft loss and sensitization post-VAD (blue boxes). Innate B cells also infiltrate cardiac allografts during CAV (blue boxes). Key unanswered questions about innate B cells and IgG Nabs are indicated in red boxes.