Table 1.
Demographic and clinical information of the three subject groups
| Subject demographics | Brain death | HIE | Normal |
|---|---|---|---|
| n | 9 | 36 | 19 |
| Age, years | 27–68 (44 ± 15.9) | 22–64 (44 ± 16.5) | 21–64 (45 ± 15.1) |
| Sex, female (F), male (M) | 3 F, 6 M | 15 F, 21 M | 10 F, 9 M |
| Cardiorespiratory arrest (n) | 9/9 | 36/36 | 0/19 |
| Time to ROSC | 3.5–40 min (29.2 ± 13.2) | 3–60 min 16.4 ± 15.0) | N/A |
| Time from ROSC to MRI | 0.1–6 days (2.2 ± 1.8) | 0.2–16 days (3.8 ± 3.0) | N/A |
| Blood pressure closest to scan time | |||
| Systolic | 81–184 (118.9 ± 33.1) | 91–164 (127.5 ± 21.1) | 110–144 (127.8 ± 11.5) |
| Diastolic | 52–141 (77.5 ± 28.1) | 53–109 (73.6 ± 15.8) | 43–91 (75.5 ± 14.1) |
| Survival (n) | 0/9 | 7/36 | N/A |
| b50 ADC – gray matter (in ADC × 10−3 mm2/s) | 0.70 ± 0.18 | 1.95 ± 0.25 | 1.79 ± 0.12 |
| b50 ADC – white matter (in ADC × 10−3 mm2/s) | 0.50 ± 0.17 | 1.44 ± 0.24 | 1.26 ± 0.14 |
Values are shown as range (mean ± standard deviation) or mean ± standard deviation unless otherwise indicated
ADC apparent diffusion coefficient, HIE hypoxic ischemic encephalopathy, MRI magnetic resonance imaging, N/A not applicable, ROSC return of spontaneous circulation