Table 3.

Random effects models of biological and maternal-related environmental variables with level (initial visit) and change over time in dependent variables

	Fluid intelligence		Crystallized intelligence		Withdrawal	Anxiety
	Baseline (SS)	Trajectory (RS)	Baseline (SS)	Trajectory (RS)	Baseline (TS)	Baseline (TS)
Ratio of affected to total chromosomes	β = − 7.9, SE = 2.1 p < 0.001	β = − 1.5, SE = 0.6 p = 0.02	β = − 4.5, SE = 3.6 p = 0.22	β = 0.7, SE = 0.9 p = 0.45	β = 6.9, SE = 1.7 p < 0.001	β = 5.5, SE = 1.9 p = 0.006
Level of FMRP expression	β = 0.7, SE = 3.0 p = 0.8	β = 1.2, SE = 0.4 p = 0.01	β = 5.3, SE = 2.8 p = 0.07	β = 0.47, SE = 0.27 p = 0.09	β = 2.3, SE = 1.7 p = 0.17	β = 0.5, SE = 1.0 p = 0.60
Closeness in the mother–child relationship	β = 6.7, SE = 2.8 p = 0.02	β = 0.2, SE = 20.8 p = 0.83	β = 8.8, SE = 2.7 p = 0.002	β = 0.73, SE = 0.39 p = 0.07	β = − 8.1, SE = 1.7 p < 0.001	β = − 4.0, SE = 2.0 p = 0.053
Maternal psychological distress	β = − 8.6, SE = 2.2 p < 0.001	β = − 0.5, SE = 1.2 p = 0.7	β = − 13.2, SE = 2.7 p < 0.001	β = − 0.7, SE = 0.6 p = 0.26	β = 5.2, SE = 2.2 p = 0.02	β = 2.5, SE = 2.7 p = 0.36

Abbreviations: SS standardized score (mean of 100, standard deviation of 15), RS raw score, TS T-score (mean of 50, standard deviation of 10), β random slope, SE standard error estimation, p p value

Italicize data represent p values < 0.05