Table 1.
Mean percent change from baseline in LDL-C levels in pivotal and extension studies
| Time point | n | Observed value, mg/dL (SD) | Observed change, mg/dL (SD) | Percent change, % (SD) |
|---|---|---|---|---|
| Baseline | 19 | 342.8 (125.87) | NA | NA |
| Week 26 | 19 | 158.4 (89.65) | − 184.4 (119.15) | −50.7 (26.77) |
| Week 78 | 19 | 161.2 (59.55) | − 181.7 (110.76) | − 49.0 (19.46) |
| Week 126 | 17 | 188.8 (120.30) | −166.8 (100.28) | −45.5 (31.35) |
| Week 256 | 14 | 143.4 (83.18) | − 224.9 (108.97) | −60.1 (18.51) |
LDL-C Low-density lipoprotein cholesterol. Values represent percent change in LDL-C levels ± SD from baseline for patients entering the long-term extension study [6]. Background lipid-lowering therapies were fixed until Week 26. Week 78 marks the beginning of the extension phase