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. 2018 Jun 20;11:50. doi: 10.1186/s13048-018-0424-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Eukaryotic mismatch repair mechanism. DNA mismatches are recognised by the mismatch recognition factor MutSα, which then prompts binding and DNA stabilisation by the MLH1-PMS2 heterodimer (MutLα). The PCNA and RFA clamp loader are able to load on at a nearby ‘nick’. MutSα activated exonuclease 1 (Exo1) excise the mismatch in a 5′ to 3′ direction and the excised fragment of DNA is removed by the DNA polymerase δ holoenzyme. DNA polymerase δ refills the DNA gap and it is ligated by DNA ligase I

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