Description
A 39-year-old morbidly obese man with a medical history of tobacco abuse and paroxysmal atrial fibrillation (Afib) on rivaroxaban presented to the emergency department with acute onset of shortness of breath and severe pleuritic chest pain. His vital signs were significant for blood pressure of 100/60 mm Hg, heart rate of 110 per minute, respiratory rate of 30 per minute and oxygen saturation of 80% on a non-rebreather mask. Physical examination was unremarkable, except for increased work of breathing. Arterial blood gas (ABG) showed pH 7.49, PaCO2 30 mm Hg and PaO2 86 mm Hg. Laboratory tests were significant for elevated troponin at 2.35 ng/mL and B-type natriuretic peptide at 309 pg/mL. ECG showed sinus tachycardia with new onset incomplete right bundle block and T-wave inversion in the right precordial and the inferior leads (figure 1A). A chest CT revealed extensive bilateral pulmonary embolism (PE), involving both main pulmonary arteries and suspected mass in the right atrium (RA). Subsequent transoesophageal echocardiogram showed markedly dilated RA, right ventricle (RV) and pulmonary artery, along with severely reduced RV systolic function, and a massive, 10 cm thrombus traversing both atria via abnormal interatrial communication, occupying the left atrial appendage (LAA) and protruding into the left ventricle (figure 1B, video 1). Lower extremity Doppler ultrasound was consistent with acute occlusive deep venous thrombosis (DVT) in the right femoral and popliteal vein. The patient was started on heparin drip and transferred to intensive care unit. A multidisciplinary decision was made to proceed with emergent sternotomy with a removal of intracardiac thrombus and closure of the abnormal interatrial communication, which was intraoperatively recognised as an ostium secundum atrial septal defect, LAA occlusion (50 mm ArtiClip) and pulmonary artery thromboembolectomy along with a temporal inferior vena cava filter placement. All procedures were performed without complications. At the 2-month follow-up visit, the patient showed expected level of convalescence.
Figure 1.
(A) ECG showing sinus tachycardia and right ventricle strain pattern. (B) Transoesophageal echocardiogram. Red arrows pointing thrombus traversing both atria via abnormal interatrial communication. LA, left atrium; RA, right atrium.
1.
Transoesophageal echocardiogram showing large thrombus in the left atrium.
Atrial septal defect (ASD) is one of the most common congenital heart diseases, which can present at any age, most commonly with the symptoms of right heart failure. Concomitant Afib is a common comorbidity. Transthoracic echocardiogram is a reasonable first-line modality in evaluation of atrial septum.1 American Heart Association 2008 guidelines recommend ASD closure predominantly in the context of RA and RV enlargement (class I), as well as in the presence of paradoxical embolisation or documented platypnoea–orthodeoxia syndrome (class IIa).2
A venous thrombus entrapment within an abnormal interatrial communication is a rare initial manifestation of ASD and a clinical emergency due to the risk of impending systemic embolisation.3 The risk is especially deemed high in the context of acute massive pulmonary embolism causing transient RA pressure elevation and consequent shunt direction reversal, from left to right into right to left, promoting paradoxical embolisation. As this circumstance is rarely documented, most clinical experience regarding the optimal treatment has been incorporated from patent foramen ovale (PFO) studies. Our patient underwent urgent surgical treatment, including simultaneous thromboembolectomy, ASD closure and LAA occlusion. This approach enabled effective treatment of the patient’s acute condition, along with prevention of both paradoxical and cardiac embolisation attributed to Afib. Concurrently, the patient required anticoagulation for secondary prevention of DVT/PE. Rivaroxaban was switched to warfarin.
Learning points.
Thrombus in transit as the rare initial manifestation of atrial septal defect (ASD).
Dual risk of systemic embolisation in patient with ASD.
The importance of timed diagnosis with echocardiography and the need for an interdisciplinary approach to manage further treatment of the trapped thrombus in ASD.
Footnotes
Contributors: DMZ, YA, VG and JKK were the physicians in charge of the patient throughout hospitalisation and follow-up. They were responsible for performing, diagnosing and discussing the imaging studies of the patient. DMZ prepared the manuscript draft, which was critically revised by VG and JKK, and approved by all authors.
Funding: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Patient consent: Obtained.
Provenance and peer review: Not commissioned; externally peer reviewed.
References
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