. 2018 Apr 3;3(2):88–95. doi: 10.1016/j.parepi.2018.03.002

Table 1.

In vitro antifilarial activity of compound against adult filarial parasite in term of MTT reduction assay.

Sample	Incubation time (in h)	Test concentrations (in mg/ml)	Absorbance at 492 nm (mean ± S.E.M.)	% reduction relative to solvent control^C, heat killed^H & treated worms^T	IC₅₀
^CControl	24	–	1.007 ± 0.03	–
^HHeat killed	0.5	–	0.325 ± 0.028	–
^TCompound	24	0.0005	0.905 ± 0.005^⁎	15
	20	0.001	0.816 ± 0.005^⁎	28.1
	14	0.002	0.709 ± 0.006^⁎	43.7	0.0032
	10	0.005	0.570 ± 0.003^⁎	64.1
	6	0.01	0.463 ± 0.008^⁎	79.8
	2	0.02	0.329 ± 0.144^⁎	99.5

^CPositive control, ^Hnegative control, ^Ttreated worm with compound.

^⁎

P value represents the level of significance P < 0.05 when comparing the mean value of absorbance observed for the formazan formed between treated and control worms.