Table 3.
Infectivity and persistence of Borrelia hermsii complemented mutants in C3H and SCID mice
| Day post inoculation | C3H mice infected with | SCID mice infected with | ||||||
|---|---|---|---|---|---|---|---|---|
| WT | Bh::Comp | Bh::UHSAS | Bh::DHSΔIR | WT | Bh::Comp | Bh::UHSAS | Bh::DHSΔIR | |
| 1 | 4/5a | 0/5 | 5/5 | 4/5 | 5/5 | 0/5** | 5/5 | 3/5 |
| 2 | 4/5 | 0/5 | 5/5 | 5/5 | 5/5 | 0/5** | 5/5 | 5/5 |
| 3 | 5/5 | 0/5b** | 5/5 | 4/5 | 5/5 | 3/5 | 5/5 | 5/5 |
| 4 | 5/5 | 4/5 | 1/5* | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
| 5 | 5/5 | 3/5 | 0/5** | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
| 6 | 5/5 | 5/5 | 0/5** | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
| 7 | 5/5 | 5/5 | 0/5** | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
| 8 | 5/5 | 5/5 | 0/5** | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
| 9 | 5/5 | 5/5 | 0/5** | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
| 10 | 5/5 | 5/5 | 0/5** | 0/5** | 5/5 | 5/5 | 5/5 | 5/5 |
SCID, severe combined immunodeficient; WT, wild type; DHS, downstream homology sequence.
a
Value listed corresponds to the number of spirochete positive mice/number tested.
b
Statistically significant difference between mutant and wild‐type B. hermsii control groups denoted by asterisks as determined by Fisher's exact test. (**p < .01, *p < .05).