Skip to main content
. 2001 Oct 16;98(22):12718–12723. doi: 10.1073/pnas.221375398

Figure 3.

Figure 3

SCH-C inhibits HIV-1 entry and replication in vitro. (A) SCH-C inhibits the entry of Env-pseudotyped HIV-1 into U87-CD4-CCR5 cells. SCH-C at the concentrations indicated was added to the cells immediately before infection with HIV-1 pseudotypes containing the envelope glycoproteins of the ADA (⧫) or YU-2 (●) isolates. The extent of infection was determined by measuring luciferase expression 3 days after infection and is plotted as a percentage of that occurring in the absence of inhibitor. (B) SCH-C has no effect on HIV-1 entry via CXCR4. U87-CD4-CCR5 cells (Left) or U87-CD4-CXCR4 cells (Right) were infected with a dual-tropic primary virus, HIV-1 P17 (solid bars) or HIV-1 2073cl.3 (hatched bars), in the presence or absence of SCH-C (1 μM) or AMD3100 (1 μM) as indicated. The extent of infection was determined by measuring p24 antigen production and is plotted as a percentage of that occurring in the absence of inhibitor.