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. 2018 Jun 22;41(6):274–283. doi: 10.1097/CJI.0000000000000229

FIGURE 2.

FIGURE 2

IL-21 instructs the generation of CD8+ TSCMs better than other common γ-chain family cytokines. A, Flow cytometry analysis of sorted human naive CD8+ T cells after the 2-week stimulation with coated anti-CD3, soluble anti-CD28 in the presence of IL-2 (10 ng/mL), IL-7 (10 ng/mL), IL-15 (10 ng/mL), or IL-21 (20 ng/mL). Data are gated on total CD8+ T cells. B, Percentages of TSCM cells obtained as described in (A). Data were presented as mean±SEM (error bars) of 6 (A, B) healthy donors. The paired t test was used. P<0.05 indicates statistically significant difference. IL-2 indicates interleukin-2; TSCM, T memory stem cell. *P<0.05; **P<0.01; ***P<0.001.