Table 6.
Factors associated with mortality in univariate and multivariate analysis in the overall PH cohort.
| Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| P | HR (95% CI) | P | HR (95% CI) | |
| Age (years) | 0.001 | 1.82 (1.28–2.59) | 0.006 | 1.03 (1.01–1.05) |
| NYHA class | <0.001 | 2.05 (1.54–2.73) | 0.26 | 0.8 (0.52–1.2) |
| Male gender | 0.003 | 1.74 (1.21–2.51) | 0.10 | 1.6 (0.9–2.8) |
| Group 3 vs. PAH | <0.001 | 2.50 (1.71–3.64) | 0.76 | 0.90 (0.48–1.7) |
| Group 4 vs. PAH | 0.04 | 0.51 (0.26–0.98) | 0.002 | 0.18 (0.06–0.53) |
| Group 5 vs. PAH | 0.22 | 0.56 (0.22–1.41) | 0.09 | 0.28 (0.06–1.2) |
| 6MWD (m)* | <0.001 | 0.996 (0.995–0.997) | <0.001 | 0.99 (0.995–0.998) |
| FVC (%)* | 0.015 | 0.99 (0.981–0.998) | 0.87 | 1.002 (0.98–1.02) |
| TLC (%)* | 0.004 | 0.985 (0.975–0.995) | 0.13 | 0.98 (0.96–1.005) |
| FEV1 (%)* | 0.06 | 0.992 (0.984–1) | – | |
| KCO (%)* | <0.001 | 0.983 (0.975–0.992) | 0.004 | 0.98 (0.97–0.99) |
| mPAP (mmHg)* | 0.8 | 1 (0.986–1.12) | – | |
| PVR (WU)* | 0.01 | 1.03 (1.008–1.06) | 0.70 | 1.01 (0.95–1.07) |
| CI (L/min/m2)* | 0.01 | 0.61 (0.46–0.81) | 0.56 | 0.87 (0.55–1.38) |
| SvO2 (%)* | <0.001 | 0.96 (0.94–0.98) | 0.13 | 0.97 (0.95–1.006) |
*
Per 1 unit increment.
PAH, pulmonary arterial hypertension.