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. 2018 May 17;3(10):e120365. doi: 10.1172/jci.insight.120365

Figure 11. PBI-4050 treatment reduced renal interstitial fibrosis in hHB-EGFTg/Tg fibrotic mice.

Figure 11

(A) Reduction of EGFR-mediated renal ERK activation and α-SMA (marker of myofibroblasts) was evident in hHB-EGFTg/Tg mice treated with PBI-4050 from 5–15 weeks of age. (B) Picrosirius red staining demonstrated decreased renal fibrosis in PBI-4050–treated hHB-EGFTg/Tg mice. (C) PBI-4050 treatment reduced renal expression levels of profibrotic and fibrotic components including connective tissue growth factor (CTGF), collagen I, α-SMA, fibronectin, and TGF-β, as well as phosphorylation of SMAD3. *P < 0.05, n = 4. Original magnification, ×63 in the upper panels of B; ×160 in A, C, and lower panels of B. All values are shown as mean ± SEM. All P values were calculated by Student’s t test.