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. 2018 May 17;3(10):e120365. doi: 10.1172/jci.insight.120365

Figure 8. PBI-4050 treatment decreased fibrosis and leukocyte infiltration in pancreas.

Figure 8

(A) PBI-4050 reduced fibrosis in pancreas islets in eNOS–/– db/db mice as shown by Picrosirius red staining; arrows show fibrotic areas. (B) Islet macrophage density was markedly lower in PBI-4050–treated eNOS–/– db/db mice compared with vehicle-treated eNOS–/– db/db mice as indicated by F4/80 staining. ***P < 0.001, n = 7 in each group. (C) Islet cytotoxic CD8 lymphocyte density was significantly lower in PBI-4050–treated eNOS–/– db/db mice compared with vehicle-treated eNOS–/– db/db mice. Arrows indicate CD8α+ cells. **P < 0.01, n = 7 in each group. Original magnification, ×250 in all. All values are shown as mean ± SEM. All P values were calculated by Student’s t test.