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. 2018 May 3;3(9):e98380. doi: 10.1172/jci.insight.98380

Figure 4. Effect of depletion of pDCs on immune cell subsets in the lung-draining lymph nodes, spleen, and lung.

Figure 4

(A–I) Animals were injected with bleomycin and treated with an anti–PDCA-1 Ab (Depleted) or an isotype-matched control Ab (Intact), as described in Supplemental Figure 2A. Lung-draining lymph nodes (LN), spleen, and lungs were harvested on day 28 and analyzed for immune cell subsets. Numbers on representative FACS plots represent the % of positive cells in the lymphocyte gate; (A–C, and G–I) or in the TCRβ+ cell gate (D-F) dots in symbol plots represent individual animals. Small horizontal lines indicate average values. Results shown are representative of 5 independent experiments, each using 4–5 animals per group. *P < 0.05, Mann-Whitney U test.