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. 2018 May 3;3(9):e98241. doi: 10.1172/jci.insight.98241

Figure 4. Early renal innate response in Il17raΔRTEC mice after disseminated candidiasis.

Figure 4

Control, Il17raΔRTEC (n = 8–14) and Il17ra–/– mice (n = 6) were subjected to systemic C. albicans infection. (A) Fungal burden was measured in the kidneys at days 2 and 5 p.i. Data for surviving Il17ra–/– mice (n = 4) are shown for day 5 p.i. (B) The kidneys of Il17ra–/–, control, and Il17raΔRTEC mice (n = 5–6) were evaluated for kidney infiltrating neutrophils (live CD45+Ly6G+CD11b+), macrophages (live CD45+F4/80+CD11b+), and NK cells (live CD45+CD3–NK1.1+) at day 2 p.i. (C) Renal transcript expression of Cxcl5, S100a8, and Defb1 was measured by qPCR in control and Il17raΔRTEC mice (n = 7–10) at day 2 p.i. Each dot represents an individual mouse, and data are represented as mean ± SD. Data are pooled from 2 independent experiments for A and B and 3 independent experiments for C and were analyzed by 1-way ANOVA. *P < 0.05; **P < 0.01; ***P < 0.001.