Table 4.
Percentage reclassified and odds ratios (OR) for reclassification from multivariable logistic regression using the TBS-adjustment to FRAX assuming fixed MOF ≥ 20% and HF ≥ 3% intervention cut-offs.
| Clinical variables | Subgroups | MOF |
HF |
||||
|---|---|---|---|---|---|---|---|
| % Reclassified Overall (Down : Up)* | OR (95% CI) | p-value | % Reclassified Overall (Down : Up)* | OR (95% CI) | p-value | ||
| All subjects | 2.5 (1.0 : 1.5) | 3.0 (0.9 : 2.1) | |||||
| Sex | Women | 2.6 (1.1 : 1.5) | 1.00 (ref) | 2.8 (0.8 : 2.0) | 1.00 (ref) | ||
| Men | 1.4 (0.5 : 0.9) | 0.37 (0.26-0.51) | <0.001 | 5.6 (2.3 : 3.2) | 1.62 (1.35-1.94) | <0.001 | |
| Age (years) | < 65 | 4.5 (2.0 : 2.5) | 3.45 (2.89-4.11) | <0.001 | 4.2 (1.0 : 3.2) | 1.92 (1.68-2.19) | <0.001 |
| ≥ 65 | 0.9 (0.2 : 0.6) | 1.00 (ref) | 2.0 (0.8 : 1.1) | 1.00 (ref) | |||
| BMI (kg/m2) | < 30 | 2.0 (0.7 : 1.3) | 0.91 (0.75-1.10) | 0.31 | 2.9 (0.7 : 2.2) | 0.93 (0.80-1.09) | 0.38 |
| ≥ 30 | 2.6 (1.1 : 1.5) | 1.00 (ref) | 3.0 (1.0 : 2.0) | 1.00 (ref) | |||
| Diabetes | Yes | 3.4 (1.0 : 2.4) | 1.22 (1.00-1.49) | 0.049 | 4.7 (0.9 : 3.8) | 1.45 (1.22-1.72) | <0.001 |
| No | 2.4 (1.0 : 1.4) | 1.00 (ref) | 2.8 (0.9 : 1.9) | 1.00 (ref) | |||
| Prior fracture | Yes | 7.3 (2.8 : 4.4) | 2.94 (2.55-3.39) | <0.001 | 5.4 (1.9 : 3.5) | 1.80 (1.56-2.08) | <0.001 |
| No | 1.7 (0.7 : 1.0) | 1.00 (ref) | 2.6 (0.8 : 1.9) | 1.00 (ref) | |||
| COPD | Yes | 4.5 (1.2 : 3.3) | 1.37 (1.13-1.67) | 0.001 | 5.2 (1.5 : 3.6) | 1.51 (1.26-1.80) | <0.001 |
| No | 2.3 (1.0 : 1.3) | 1.00 (ref) | 2.8 (0.9 : 1.9) | 1.00 (ref) | |||
| High alcohol use | Yes | 4.4 (1.3 : 3.1) | 2.01 (1.44-2.79) | <0.001 | 4.8 (1.7 : 3.0) | 1.57 (1.16-2.12) | 0.003 |
| No | 2.4 (1.0 : 1.4) | 1.00 (ref) | 2.9 (0.9 : 2.0) | 1.00 (ref) | |||
| Rheumatoid arthritis | Yes | 4.9 (2.2 : 2.7) | 1.66 (1.24-2.22) | <0.001 | 4.9 (1.7 : 3.1) | 1.46 (1.11-1.92) | 0.006 |
| No | 2.4 (1.0 : 1.4) | 1.00 (ref) | 2.9 (0.9 : 2.0) | 1.00 (ref) | |||
| Glucocorticoid use | Yes | 4.9 (2.2 : 2.7) | 2.21 (1.74-2.81) | <0.001 | 5.3 (2.5 : 2.8) | 1.50 (1.20-1.87) | <0.001 |
| No | 2.3 (0.9 : 1.4) | 1.00 (ref) | 2.8 (0.8 : 2.0) | 1.00 (ref) | |||
| Secondary osteoporosis | Yes | 2.6 (0.9 : 1.6) | 1.01 (0.81-1.24) | 0.96 | 3.5 (1.4 : 2.1) | 1.09 (0.91-1.31) | 0.36 |
| No | 2.5 (1.0 : 1.5) | 1.00 | 2.9 (0.9 : 2.1) | 1.00 | |||
| Femoral neck osteoporosis | Yes | 9.2 (4.2 : 5.0) | 3.65 (3.16-4.22) | <0.001 | 5.2 (3.4 : 1.8) | 1.34 (1.15-1.57) | <0.001 |
| No | 1.5 (0.6 : 1.0) | 1.00 (ref) | 2.7 (0.6 : 2.1) | 1.00 (ref) | |||
| Osteoporosis treatment | Yes | 2.1 (1.0 : 1.1) | 0.79 (0.67-0.95) | 0.010 | 2.4 (0.9 : 1.5) | 0.80 (0.68-0.94) | 0.007 |
| No | 2.6 (1.0 : 1.6) | 1.00 (ref) | 3.2 (0.9 : 2.2) | 1.00 (ref) | |||
| Comorbidity | High | 3.4 (1.3 : 2.1) | 1.26 (1.01-1.57) | 0.105 | 3.5 (1 : 2.5) | 1.04 (0.86-1.25) | |
| Moderate | 2.3 (1.1 : 1.2) | 1.17 (0.95-1.45) | 2.9 (0.9 : 2.0) | 1.07 (0.90-1.27) | 0.73 | ||
| Low | 1.5 (0.4 : 1.1) | 1.00 (ref) | 2.3 (0.8 : 1.5) | 1.00 (ref) | |||
Significant effects are in bold.
*
Down: Reclassification from treatment to non-treatment; Up: Reclassification from non-treatment to treatment, BMI body mass index, COPD chronic obstructive pulmonary disease.