Table 1. SNPs of immune related genes in chromosome 17 from FM cohorts and transmission analysis from FM trios^1,2,3.

			FM Patients
Gene	AA Change	AA Pos	Ref Allele	Hetero	Homo	Var Allele	MAF	ExAc Freq
CCL11	Ala>Thr	23	65	29	6	41	20.50%	18.32%
CCL8	Lys>Gln	69	76	22	2	26	13.00%	15.51%
CCL23	Val>Met	123	4	26	70	166	83.00%	81.03%
CCL4	Ser>Thr	80	53	41	6	53	26.50%	23.22%
			Ref Allele	Hetero	Homo	Var allele	MAF	ExAC Freq
CCL11	Ala>Thr	23	139	72	9	90	20.45%	18.32%
CCL8	Lys>Gln	69	86	30	4	38	15.83%	15.31%
CCL23	Met>Val	123	80	33	7	47	19.58%	18.97%
CCL4	Ser>Thr	80	129	88	9	105	24.09%	23.22%
			Transmitted		Not Transmitted		P value
CCL11	Ala>Thr	23	81		52		0.0074
CCL8	Lys>Gln	69	33		37		NS
CCL23	Met>Val	123	42		36		NS
CCL4	Ser>Thr	80	80		77		NS

¹ Upper: raw Illumina sequencing data of 100 FM patients taken from S1 Table. MAF = minor allele frequency. Note: for CCL23 in the ExAc dbase Val>Met is reported as the MAF (bold type), but should be Met>Val. This discrepancy is corrected in the validation section (Middle). NS, not significant.

² Middle: validated data by direct sequencing of 220 FM samples for CCL11 and CCL4, and 120 FM samples for CCL8 and CCL23. The corrected minor allele for CCL11 (Val) and the MAF are shown in bold.

³ Lower: transmission analysis includes 220 trios for CCL11 and CCL4, and 120 trios for CCL8 and CCL23. P-values are one-sided on the presumption that the variant allele confers higher risk of FM.