Table 2. Hematological measures in acutely treated mice.
Parameters | Units | Vehicle (mean ± SD) |
LPS (mean ± SD) |
SR12343 (mean ± SD) |
---|---|---|---|---|
Leukocytes | ||||
White blood cells | K/μL | 6.9 ± 5.3 | 7.9 ± 4.6 | 7.4 ± 3.3 |
Neutrophils | K/μL | 1.8 ± 2.1 | 2.3 ± 1.5 | 2.1 ± 1.3 |
Lymphocytes | K/μL | 3.8 ± 2.2 | 4.4 ± 2.4 | 4.0 ± 1.3 |
Monocytes | K/μL | 0.8 ± 0.4 | 0.5 ± 0.3 | 0.5 ± 0.2 |
Eosinophils | K/μL | 0.3 ± 0.5 | 0.5 ± 0.3 | 0.6 ± 0.4 |
Basophils | K/μL | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.2 |
Neutrophils | % | 21.5 ± 9.9 | 27.7 ± 4.6 | 26.3 ± 8.0 |
Lymphocytes | % | 60.8 ± 11.7 | 56.6 ± 5.6 | 57.7 ± 14.2 |
Monocytes | % | 12.9 ± 3.5 | 6.3 ± 0.9 | 6.0 ± 0.7 |
Eosinophils | % | 3.4 ± 2.8 | 6.9 ± 1.7 | 7.3 ± 3.7 |
Basophils | % | 1.4 ± 0.8 | 2.5 ± 1.5 | 2.7 ± 2.0 |
Erythrocytes | ||||
Red blood cells | M/μL | 9.9 ± 1.1 | 10.6 ± 0.6 | 10.4 ± 0.3 |
Hemoglobin | g/dL | 14.7 ± 0.8 | 15.2 ± 0.4 | 15.3 ± 0.4 |
Hematocrit | % | 49.0 ± 2.2 | 52.3 ± 3.3 | 53.0 ± 1.5 |
Mean corpuscular volume | fL | 49.7 ± 3.3 | 49.5 ± 0.9 | 51.2 ± 1.0 |
Mean corpuscular hemoglobin | pg | 14.9 ± 0.8 | 14.4 ± 0.5 | 14.8 ± 0.2 |
Mean corpuscular hemoglobin concentration | g/dL | 30.1 ± 0.4 | 29.2 ± 1.2 | 28.9 ± 0.2 |
Red cell distribution width | % | 16.1 ± 1.1 | 16.0 ± 0.9 | 15.0 ± 0.2 |
Thrombocytes | ||||
Platelets | K/μL | 126.3 ± 58.8 | 133.7 ± 127.0 | 170.7 ± 64.0 |
Mean platelet volume | fL | 5.8 ± 0.7 | 5.2 ± 0.4 | 5.7 ± 0.8 |
Abbreviations: LPS, lipopolysaccharide; SD, standard deviation.