Table 1.

Simulators used in this study. Stochastic simulation algorithm (SSA) used in each of the simulators is listed along with the language they are implemented with.

Approach	Simulator	SSA Method	Language	Version	Reference
Network-based	BioNetGen	SDM *	Perl and C++	2.3.1	[17]
	COPASI_D	DM **	C++	4.21 (Build 166)	[6]
	COPASI_GB	NRM ***	C++	4.21 (Build 166)	[6]
	Dizzy	DM	Java	1.11.4	[9]
	Gillespie2	DM	C	Rev: 56	[10]
	pSSAlib_SPDM	SPDM #	C++	2.0.0	[13]
	pSSAlib_SSACR	CR ##	C++	2.0.0	[13]
	RoadRunner	DM	C	1.4.24	[12]
	SGNS2	NRM	C++	2.1.170	[11]
	StochKit2	CR	C++	2.0.13	[33]
	StochPy	DM	Python	2.3	[8]
Network-free	DYNSTOC	—	C	1.2.0	[25]
	KaSim	—	OCaml	3.5	[22]
	NFsim	—	C++	1.11	[19]
	RuleMonkey	—	C	2.0.25	[39]

^*Sorting direct method;

^**Direct method;

^***Next reaction method;

^#Sorting partial propensity direct method;

^##Composition rejection method.