Skip to main content
. Author manuscript; available in PMC: 2018 Jun 21.
Published in final edited form as: SIAM Rev Soc Ind Appl Math. 2016 Nov 3;58(4):716–736. doi: 10.1137/15M1044825

Fig. 2.3. Markov Point Mutation Diagram.

Fig. 2.3

Left: diagram shows 16 genetic cell types based on 4-digit binary string and the effect of a point mutation on each cell type. Blue indicates healthy cell type (0000 — 1010), red indicates cancerous cell type (1011 — 1111). Black arrows indicate passenger mutations (healthy to healthy or cancer to cancer), red arrows indicate driver mutations (healthy to cancer). Top right: 3 scenarios may occur during the reproduction process: no mutation, passenger mutation, or driver mutation.