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. 2018 Jul;120:74–83. doi: 10.1016/j.yjmcc.2018.05.015

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 2 — BB attenuated electrical remodeling. Telemetric recording of ECGs during the light (inactive) period on day 1, day 15 (prior to vehicle or BB treatment) and final experimental day. A On the final day there was a decrease in RR interval in MCT animals compared to CON, this effect was attenuated by BB treatment. B BB treatment significantly reduced the QT prolongation seen in MCT. C Final day mRNA levels for channels carrying repolarising K⁺ currents were significantly reduced in MCT compared with CON. For the main channel carrying I_K1 there was intermediate expression in MCT + BB animals for Kir2.1. D Final day mRNA levels for K⁺ channel subunits KChap and KChIP2 did not vary between groups but the expression of the Kv regulator Nfatc3 was reduced in MCT compared with CON, while MCT + BB hearts showed intermediate levels. A, BN = 9–12 animal in each group, two-way ANOVA. C, DN = 10 animals in each group, one-way ANOVA. *P < .05, **P < .01, ***P < .001.