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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Genes Brain Behav. 2018 Feb 15;17(6):e12452. doi: 10.1111/gbb.12452

Figure 3.

Figure 3

Ube3a mice displayed deficits on rotarod motor coordination and balance. Each test consisted of 5 minutes on an Ugo Basile mouse rotarod, accelerating from 4 to 40 rpm, with latency to fall as the dependent variable. Each subject mouse was given three trials within one day, to evaluate motor coordination and balance. Latency to fall from the rotarod was shorter in Ube3a as compared to WT on the first test trial, indicating impaired motor coordination and balance, consistent with previous reports. Latency to fall was similarly shorter in Ube3a on subsequent test trials, although a trend for improved performance across the three test trials indicated that some motor learning may have occurred. N = 12 WT, 12 Ube3a, *p < 0.001.