Table 4.
Hazard ratios (95% confidence interval) for hip fracture over 15 years of follow-up for tertiles of baseline leg and total lean mass among women in the Framingham Osteoporosis Study (1992–2007)
| Model 1a | Model 2b | Model 3c | Model 4d | |
|---|---|---|---|---|
| Leg lean mass | ||||
| Tertile 1 (n=659) | 1.0 | 1.0 | 1.0 | 1.0 |
| Tertile 2 (n=659) | 0.89 (0.56, 1.41) | 1.08 (0.67, 1.56) | 1.32 (0.80, 2.18) | 1.40 (0.78, 2.51) |
| Tertile 3 (n=659) | 0.68 (0.42, 1.13) | 1.03 (0.57, 1.86) | 1.05 (0.57, 1.95) | 1.47 (0.72, 3.01) |
| Total lean mass (n=1,812) | ||||
| Tertile 1 (n=659) | 1.0 | 1.0 | 1.0 | 1.0 |
| Tertile 2 (n=659) | 0.68 (0.42, 1.10) | 1.04 (0.62, 1.73) | 1.27 (0.75, 2.15) | 1.42 (0.76, 2.64) |
| Tertile 3 (n=659) | 0.69 (0.42, 1.11) | 1.36 (0.75, 2.44) | 1.42 (0.76, 2.64) | 1.95 (0.95, 3.99) |
a
Model 1 unadjusted
b
Model 2 includes age, height, cohort, % body fat
c
Model 3 additionally adjusts for femoral neck BMD
d
Model 4 additionally adjusts for history of hip fracture, smoking, physical activity, estrogen replacement use, osteoporosis medication use