Table 3.
The p-values of genes with suggestive evidence of gene-level GxE effects in the- meta-analysis of gene-age interactions for the; EOBC and the ROOT data analysis. Genes with p-values less than 10−5 are listed. The gene TMEM206 is significant at the genome-wide significance threshold of 0.05 in the EOBC data analysis (p-value threshold = 0.05/14631 = 3.42×10−6). The gene LOC101928278 is significant at the genome-wide significance threshold of 0.05 in the ROOT data analysis (p-value threshold is 0.05/17547 = 2.85 × 10−6).
| Consortium | Sample size (Case/Control) | Gene | Gene size (k) | p_random.MF | p_fixed.MF | p_ofGEM |
|---|---|---|---|---|---|---|
| EOBC | 4,969 (2,540/2,429) | FAM91A1 | 9 | 5.13×10−3 | 7.80×10−5 | 6.30×10−6 |
| TMEM206 | 12 | 2.94×10−3 | 2.60×10−5 | 1.33×0−6 | ||
|
| ||||||
| ROOT | 3,685 (1,657/2,028) | LOG101928278 | 5 | 2.10×10−5 | 1.89×10−3 | 7.15×10−7 |
| SIAH2 | 11 | 3.60×10−2 | 1.20×10−5 | 6.77×10−6 | ||