Table 3.

Effect Estimates for change in HRQL over time from before through six months after lung transplantation

Instrument	Instrument Type	ECMO n=17	Inpatient n=48	Outpatient n=124	p- value
SF12-PCS (MCID=5)	Generic-Physical	16.78 (10.65, 21.91)	19.56 (15.62, 23.50)	20.78 (18.50, 23.07)	0.27
SF12-MCS (MCID=5)	Generic-Mental	8.78 (3.31, 14.26)	7.48 (3.97, 10.99)	4.48 (2.47, 6.49)	0.01
AQ20R (MCID=1.75)	Respiratory Specific	10.76 (8.57, 12.96)	9.84 (8.45, 11.23)	9.76 (8.96, 10.56)	0.59
EQ5D (MCID=0.06)	Health Utility	0.31 (0.20, 0.42)	0.29 (0.22, 0.36)	0.17 (0.13, 0.21)	0.001
GDS (MCID=1.65)	Depression Scale	4.81 (3.15, 6.48)	3.43 (2.38, 4.49)	3.54 (2.94, 4.14)	0.09

Data presented as mean effect estimates with 95% confidence intervals as quantified by segmented linear mixed effects models with a joint point at six months. Models were adjusted for age, sex, diagnosis, preoperative forced expiratory volume in 1 second, six-minute walk distance, and lung allocation score.

HRQL Instruments: Generic Physical Instrument: SF12-PCS (Short Form 12 – Physical Component Score) Range 0–100; Generic Mental Instrument: SF12-MCS (Short Form 12 – Mental Component Score) Range 0–100; Respiratory-Specific Instrument: AQ20R (Airways Questionnaire 20-Revised) Range 0–20 – reverse coded for analysis; Health-Utility Instrument: EQ5D (EuroQoL 5D) Range −1.11 – 1; Depression Scale: GDS (Geriatric Depression Scale) Range: 0–15 – reverse coded for analysis