Table 2.
Relative risks chronic liver disease in relation to occurrence of the same diseases in the contributing blood donor(s), presented overall and by latency in the donors before 1992.*
| Donor diseased
|
Donor not diseased
|
|||
|---|---|---|---|---|
| Disease | Events/person-years | Hazard ratio (95% CI)† | Events/person-years | Hazard ratio(95% CI)† |
| a) Patients transfused before 1992 | ||||
| All liver disease | 1,461/377,543 | 1.38 (1.30-1.46) | 8,590/3,874,257 | 1.00 (ref) |
| <5 year latency | 180/36,075 | 1.73 (1.48-2.02) | ||
| 5-10 year latency | 191/48,855 | 1.37 (1.18-1.59) | 8,590/3,874,257 | 1.00 (ref) |
| >10 years latency | 1,090/292,613 | 1.34 (1.25-1.43) | ||
| All liver disease (excluding viral hepatitis) | 912/337,044 | 1.08 (1.00-1.16) | 7,658/3,930,336 | 1.00 (ref) |
| <5 year latency | 93/28,058 | 1.34 (1.08-1.65) | ||
| 5-10 year latency | 111/42,195 | 1.01 (0.83-1.22) | 7,658/3,930,336 | 1.00 (ref) |
| >10 years latency | 708/266,791 | 1.07 (0.98-1.16) | ||
| Liver cirrhosis | 91/83,706 | 1.34 (1.08-1.67) | 2,242/4,213,467 | 1.00 (ref) |
| <5 year latency | 9/5,961 | 2.27 (1.16-4.45) | ||
| 5-10 year latency | 11/9,333 | 1.57 (0.86-2.87) | 2,242/4,213,467 | 1.00 (ref) |
| >10 years latency | 71/68,412 | 1.25 (0.97-1.59) | ||
| Viral hepatitis | 359/82,841 | 6.26 (5.54-7.08) | 2,242/4,213,467 | 1.00 (ref) |
| <5 year latency | 66/12,761 | 7.29 (5.57-9.55) | ||
| 5-10 year latency | 53/12,112 | 7.23 (5.44-9.59) | 2,242/4,213,467 | 1.00 (ref) |
| >10 years latency | 240/57,968 | 5.86 (5.07-6.77) | ||
|
| ||||
| b) Patients transfused in or after 1992 | ||||
| All liver disease | 692/188,377 | 0.99 (0.91-1.07) | 21,672/7,059,794 | 1.00 (ref) |
| <5 year latency | 216/49,916 | 1.00 (0.87-1.16) | ||
| 5-10 year latency | 214/63,155 | 0.89 (0.77-1.02) | 21,672/7,059,794 | 1.00 (ref) |
| >10 years latency | 262/75,306 | 1.06 (0.94-1.21) | ||
| All liver disease (excluding viral hepatitis) | 570/174,502 | 0.99 (0.91-1.09) | 19,443/7,086,443 | 1.00 (ref) |
| <5 year latency | 178/44,736 | 1.03 (0.88-1.21) | ||
| 5-10 year latency | 175/58,152 | 0.90 (0.76-1.05) | 19,443/7,086,443 | 1.00 (ref) |
| >10 years latency | 217/71,614 | 1.05 (0.91-1.21) | ||
| Liver cirrhosis | 7/19,881 | 0.52 (0.23-1.18) | 3,630/7,280,689 | 1.00 (ref) |
| <5 year latency | 1/3,242 | 0.53 (0.07-3.77) | ||
| 5-10 year latency | 2/5,591 | 0.28 (0.04-1.83) | 3,630/7,280,689 | 1.00 (ref) |
| >10 years latency | 4/11,048 | 0.68 (0.25-1.83) | ||
| Viral hepatitis | 15/18,996 | 1.12 (0.62-2.02) | 3,099/7,272,465 | 1.00 (ref) |
| <5 year latency | 5/6,322 | 1.53 (0.62-3.81) | ||
| 5-10 year latency | 5/6,736 | 0.76 (0.24-2.43) | 3,099/7,272,465 | 1.00 (ref) |
| >10 years latency | 5/5,938 | 1.14 (0.42-3.15) | ||