Table 2.
Aging | Natalizumab | Fingolimod | DMF | Anti-CD20 | Teriflunomide | Alemtuzumab | ||
---|---|---|---|---|---|---|---|---|
PERIPHERY | CD19+ B cells | ▼ | ▲ | ▼▼ | ▼▼ | ▼▼▼ | ▼▼ | ▼▼ |
B memory | ▽ | △ | ▽ | ▽ | ▽ | ▭ | ▽ | |
B naïve | △ | ▽ | △ | △ | △ | ▭ | △ | |
B regulatory | ▽ | △ | △ | △ | △ | ▭ | △ | |
CD3+ T cells | ▼ | ▲ | ▼▼ | ▼▼ | ▼ | ▼ | ▼▼▼ | |
T naïve | ▽ | ▽ | ▽ | △ | ▭ | ▭ | ▽ | |
T memory | △ | △ | △ | ▽ | ▭ | ▭ | △ | |
T regulatory | △ | ▽ | △ | ▭ | ▭ | ▭ | △ | |
CD4+ T cells | ▼ | ▬ | ▼▼ | ▼ | ▬/▼ | ▼ | ▼▼▼ | |
TCentral Memory | ▭/△ | ▭/△ | ▽ | ▽ | ▽ | |||
TEffector Memory | △ | △ | △ | ▽ | △ | |||
THelper 1 | ▽ | △ | ▽ | ▽ | ▽ | |||
THelper 17 | ▽ | △ | ▽ | ▽ | ▽ | |||
THelper 2 | △ | ▽ | △ | △ | ||||
CD8+ T cells | ▼ | ▬/▲ | ▼ | ▼▼ | ▬ | ▼ | ▼▼▼ | |
TCentral Memory | △ | ▭ | ▽ | ▭ | ▽ | |||
TEffector Memory | △ | △ | ▭ | ▽ | △ | |||
TEMRA | △ | △ | △ | ▭ | △ | |||
CD4+/CD8+ | ▼ | ▬/▼ | ▼ | ▲ | ▬/▼ | ▲ | ▼ | |
CNS | CD19+ B cells | ▼▼ | ▼ | ▼▼▼ | ||||
B memory | ▽ | ▽ | ||||||
B naïve | ▽ | |||||||
B regulatory | △ | |||||||
CD3+ T cells | ▼▼ | ▼▼ | ▼▼ | |||||
CD4+ T cells | ▼▼ | ▼▼ | ||||||
CD8+ T cells | ▼ | ▼ | ||||||
T regulatory | ||||||||
CD4+/CD8+ | ▼ | ▼ |
Bold font and closed symbols indicates changes in absolute cell numbers.
Regular font and open symbols indicates relative changes.
▲ Increase, ▼ Decrease, ▬ No change, use of / indicates different effects in different subsets of patients. Magnitude of absolute cell count changes noted by number of symbols. Empty boxes indicate no reported data.