Figure 2.
Effect of ODQ or zaprinast on the cytostatic actions of DETA/NO, SNAP, and DFMO in RASMC. Cell proliferation was assessed by thymidine incorporation into DNA during 24-h incubation, as described in Materials and Methods. ODQ (10 μM) or zaprinast (30 μM) was added to cells at the same time as test agents. Data were calculated as dpm/105 cells and expressed as percent of control (assigned 100%), where control represents cells grown in the absence of added test agents. Values for DETA/NO, SNAP, and DFMO were not significantly (P > 0.05) different from corresponding values in the presence of ODQ or zaprinast. Data represent mean ± SE of duplicate determinations from three to four experiments.