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Activation of the p42/p44 MAPK pathway and induction of p21waf1/cip1 by SNAP, DETA/NO, or DFMO in RASMC. Whole-cell lysates of RASMC treated for 24 h with 30 μM SNAP, 100 μM DETA/NO, or 300 μM DFMO were subjected to Western blot analysis for p21waf1/cip1, phosphorylated p42/p44, or p42/p44, as described in Materials and Methods. Control represents RASMC grown in the absence of added test agents. Data are representative of three separate experiments.
